Human Herpesvirus 8: Current Issues

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Human herpesvirus 8: current issues.

Although human herpesvirus 8 (HHV-8) is the etiologic agent of Kaposi sarcoma (KS), there are no formal guidelines for the clinical management of HHV-8 infection. In patients infected with human immunodeficiency virus (HIV), highly active antiretroviral therapy (HAART) is the best tool for the prevention of KS. In patients who have undergone transplantation, KS is often managed by curtailing im...

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[Human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus].

Human herpesvirus 8 (HHV-8), a gammaherpesvirus implicated in Kaposi's sarcoma, primary effusion lymphoma, and Castleman's disease, encodes several pathogenically important cellular homologs. To define the HHV-8 transcription program, RNA obtained from latently infected body cavity-based lymphoma 1 cells induced to undergo lytic replication was used to query a custom HHV-8 DNA microarray contai...

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Multiple human herpesvirus-8 infection.

In Malawian patients with Kaposi sarcoma (KS) and their relatives, we investigated nucleotide-sequence variation in human herpesvirus-8 (HHV-8) subgenomic DNA, amplified from oral and blood samples by use of polymerase chain reaction. Twenty-four people had amplifiable HHV-8 DNA in >1 sample; 9 (38%) were seropositive for human immunodeficiency virus type 1, 21 (88%) were anti-HHV-8-seropositiv...

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Human Herpesvirus 8 Seroprevalence, China

To summarize the seroprevalence of human herpesvirus 8 (HHV-8) in mainland China, we conducted a systematic review and meta-analysis based on available literature. Data show that differences in HHV-8 prevalence vary considerably among different ethnic groups and geographic regions. Blood-borne transmission could be a potential route for HHV-8 infection in China.

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1. Calisher CH, Childs JE, Field HE, Holmes KV, Schountz T. Bats: important reservoir hosts of emerging viruses. Clin Microbiol Rev. 2006;19:531–45. DOI: 10.1128/ CMR.00017-06 2. Wong S, Lau S, Woo P, Yuen K-Y. Bats as a continuing source of emerging infections in humans. Rev Med Virol. 2007;17:67– 91. DOI: 10.1002/rmv.520 3. Wibbelt G, Speck S, Field H. Methods for assessing diseases in bats. ...

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ژورنال

عنوان ژورنال: Clinical Infectious Diseases

سال: 2003

ISSN: 1058-4838,1537-6591

DOI: 10.1086/375230